{"id":196377,"date":"2022-07-06T08:25:32","date_gmt":"2022-07-06T06:25:32","guid":{"rendered":"https:\/\/ew-nutrition.com\/pushing-microbiome-in-right-direction-phytomolecules\/"},"modified":"2023-10-11T14:08:12","modified_gmt":"2023-10-11T12:08:12","slug":"pushing-microbiome-in-right-direction-phytomolecules","status":"publish","type":"post","link":"https:\/\/ew-nutrition.com\/es\/pushing-microbiome-in-right-direction-phytomolecules\/","title":{"rendered":"Modulaci\u00f3n eficiente del microbioma con fitomol\u00e9culas"},"content":{"rendered":"<p><span style=\"font-size: 12pt;\"><em>Por\u00a0<\/em><strong><em>el Dr. Inge Heinzl<\/em><\/strong><em>, Editora, EW Nutrition<\/em><\/span><\/p>\n<p><strong>Desde el d\u00eda 1, los animales j\u00f3venes se enfrentan a los pat\u00f3genos de su entorno. Los alimentos y los ingredientes de los alimentos tambi\u00e9n aumentan significativamente la exposici\u00f3n a los microbios. Este art\u00edculo analizar\u00e1 de cerca tres bacterias cr\u00edticas en la producci\u00f3n av\u00edcola. Los ensayos de productos a base de fitomol\u00e9culas compartidos en este art\u00edculo demuestran el beneficio \u00fanico de reducir los pat\u00f3genos da\u00f1inos y, al mismo tiempo, preservar los microorganismos que promueven la salud. La selecci\u00f3n espec\u00edfica de las fitomol\u00e9culas de la mezcla contribuye a este modo de acci\u00f3n distintivo.<\/strong><\/p>\n<h2><i><span lang=\"EN-US\">E. coli<\/span><\/i><span lang=\"EN-US\"> puede ser valioso&#8230; y peligroso<\/span><\/h2>\n<ol>\n<li>coli son bacterias comensales que generalmente pertenecen a la flora intestinal natural. Sin embargo, hay varias cepas de E. coli que, debido a ciertos factores de virulencia, pueden causar enfermedades. Estas bacterias se llaman E. coli pat\u00f3gena aviar o (APEC por sus siglas en ingl\u00e9s). La enfermedad &#8216;colibacilosis&#8217; puede ocurrir en diferentes formas:<\/li>\n<\/ol>\n<ul>\n<li>Onfalitis: una infecci\u00f3n no contagiosa del ombligo y \/ o saco vitelino en aves j\u00f3venes<\/li>\n<li>Peritonitis \u2013 respuesta inflamatoria en la &#8220;colocaci\u00f3n interna&#8221; (material vitelino en el peritoneo)<\/li>\n<li>Salpingitis \u2013 inflamaci\u00f3n del oviducto<\/li>\n<li>Celulitis \u2013 decoloraci\u00f3n y engrosamiento de la piel, inflamaci\u00f3n de los tejidos subcut\u00e1neos<\/li>\n<li>Sinovitis \u2013 cojera con articulaciones inflamadas<\/li>\n<li>Coligranuloma (enfermedad de Hj\u00e4rre) \u2013 lesiones similares a la tuberculosis, no de importancia econ\u00f3mica<\/li>\n<li>Meningitis, y<\/li>\n<li>Septicemia o envenenamiento de la sangre.<\/li>\n<\/ul>\n<p>Dado que algunas de las\u00a0<em>cepas de E. coli<\/em>\u00a0a veces pueden transmitirse verticalmente a la descendencia, es crucial mantener la presi\u00f3n pat\u00f3gena en la generaci\u00f3n parental lo m\u00e1s baja posible (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.poultryworld.net\/health-nutrition\/escherichia-coli-infections-in-broiler-production\/#:~:text=The%20recommendations%20follow%20a%20ProHealth,coli%20was%20the%20dominant%20condition.\" target=\"_blank\" rel=\"noopener\">Mc Dougal, 2018<\/a><\/span>).<\/p>\n<p>Debido al uso com\u00fan de antibi\u00f3ticos, principalmente en pollitos j\u00f3venes,\u00a0<em>se han desarrollado cepas de E. coli resistentes a los antibi\u00f3ticos \u00df-lact\u00e1micos (E. coli<\/em>\u00a0productora\u00a0<em>de BLEE) o fluoroquinolonas (por ejemplo, enrofloxacina).<\/em><\/p>\n<h2>Clostridium perfringens: la causa de la enteritis necr\u00f3tica<\/h2>\n<p><em>Clostridium perfringens<\/em>\u00a0pertenece a la flora cecal normal. Sin embargo, su crecimiento excesivo en el intestino est\u00e1 relacionado con\u00a0<span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/necrotic-enteritis-complete-overview\/\" target=\"_blank\" rel=\"noopener\">la enteritis<\/a><\/span>, necr\u00f3tica, causando p\u00e9rdidas estimadas de hasta USD 6 mil millones anuales en la producci\u00f3n av\u00edcola mundial, lo que corresponde a USD 0.0625 por ave (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1016\/j.vetmic.2015.09.019\" target=\"_blank\" rel=\"noopener\">Wade y Keyburn, 2015<\/a><\/span>). La enteritis necr\u00f3tica puede ocurrir en una forma cl\u00ednica y subcl\u00ednica.<\/p>\n<p>En el caso de la enteritis necr\u00f3tica cl\u00ednica, las aves sufren diarrea que resulta en heces h\u00famedas y aumento de la mortalidad de la parvada de hasta un 1% por d\u00eda (Ducatelle y Van Immerseel, 2010). Las tasas de mortalidad a veces suman el 50% (Van der Sluis, 2013). Si las aves mueren sin signos cl\u00ednicos, puede ser enteritis necr\u00f3tica peraguda.<\/p>\n<p>La versi\u00f3n subcl\u00ednica, sin embargo, es m\u00e1s cr\u00edtica. Debido a la falta de s\u00edntomas, a menudo no se detecta y, por lo tanto, no se trata. Principalmente a trav\u00e9s de la utilizaci\u00f3n deficiente de los alimentos, que representan el 65-75% de los costos totales en la producci\u00f3n de pollos de engorda, la enteritis necr\u00f3tica subcl\u00ednica afecta permanentemente la eficiencia de la producci\u00f3n (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/necrotic-enteritis-complete-overview\/\" target=\"_blank\" rel=\"noopener\">Heinzl et al., 2020<\/a><\/span>).<\/p>\n<h2>Salmonella ent\u00e9rica: una zoonosis relevante para aves y humanos<\/h2>\n<p>Lo m\u00e1s preocupante en la salmonelosis (no tifoidea) es que puede transferirse a los humanos. La transmisi\u00f3n ocurre a trav\u00e9s del contacto directo con un animal infectado, el consumo de productos animales contaminados como carne o huevos, el contacto con vectores infectados (insectos o mascotas) o equipos contaminados, o la contaminaci\u00f3n cruzada en la cocina. Los productos de pollo congelados o crudos, as\u00ed como los huevos, son causas frecuentes de infecciones por Salmonella de origen animal en humanos.<\/p>\n<p>La salmonela es m\u00e1s cr\u00edtica cuanto m\u00e1s j\u00f3venes son las aves. \u00a0Si los huevos para incubar ya portan salmonelas, la incubabilidad disminuye. Durante sus primeras semanas de vida, los pollitos infectados muestran una mayor mortalidad e infecciones sist\u00e9micas.<\/p>\n<p>Los animales adultos generalmente no mueren de salmonelosis; a menudo, la infecci\u00f3n pasa desapercibida. Durante un brote agudo de salmonela, los animales pueden mostrar debilidad y diarrea. Pierden peso, lo que resulta en una disminuci\u00f3n de la producci\u00f3n de huevos en las ponedoras.<\/p>\n<h2>Los ensayos con fitomol\u00e9culas muestran resultados prometedores<\/h2>\n<p>Para comprobar si los productos a base de fitomol\u00e9culas pueden influir eficazmente en la flora intestinal, se prob\u00f3 un producto especialmente dise\u00f1ado para la salud intestinal (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/animal-nutrition\/products\/ventar-d\/\" target=\"_blank\" rel=\"noopener\">Ventar D<\/a><\/span>) por su actividad antimicrobiana. Adem\u00e1s, se evalu\u00f3 el grado en que la misma mezcla afect\u00f3 a las bacterias beneficiosas, como los lactobacilos.<\/p>\n<h4>Ensayo 1: Las fitomol\u00e9culas act\u00faan contra E. coli y Salmonella ent\u00e9rica<\/h4>\n<p>El estudio in vitro utilizando el m\u00e9todo de diluci\u00f3n de agar se llev\u00f3 a cabo en un laboratorio alem\u00e1n.<\/p>\n<p>Las bacterias (<em>Salmonella typhimurium<\/em>\u00a0y E. coli productora\u00a0<em>de BLEE) almacenadas a -80\u00b0C se reactivaron cultiv\u00e1ndolas en Agar Mueller Hinton durante la noche. Despu\u00e9s de esta incubaci\u00f3n, algunas colonias fueron recogidas y suspendidas en 1 ml de soluci\u00f3n de NaCl al 0,9%. Se pipetearon 100 \u03bcl de la suspensi\u00f3n y se distribuyeron uniformemente (t\u00e9cnica de propagaci\u00f3n en placa) en el nuevo Agar Mueller Hinton que conten\u00eda diferentes concentraciones de un producto a base de fitomol\u00e9culas (Ventar D): 0 \u03bcg\/mL \u2013 control; 500 \u03bcg\/ml; 900 \u03bcg\/ml; 1.250 \u03bcg\/mL y 2.500 \u03bcg\/mL. Despu\u00e9s de 16-20 h de incubaci\u00f3n a 37\u00b0C, se evalu\u00f3 el crecimiento. Los resultados se pueden ver en las im\u00e1genes 1 y 2:<\/em><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"wp-image-101309 size-full aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e.jpg\" alt=\"\" width=\"600\" height=\"402\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e.jpg 600w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-300x201.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-150x101.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-120x80.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-36x24.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-225x151.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-80x54.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-48x32.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-64x43.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-28x19.jpg 28w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><span style=\"font-size: 10pt;\"><em>Figura 1: E. coli expuesta a diferentes concentraciones de Ventar D (fila superior de izquierda a derecha: control 0 \u03bcg\/ml, 500 \u03bcg\/ml, 900 \u03bcg\/ml; fila inferior de izquierda a derecha: 1250 \u03bcg\/ml y 2500 \u03bcg\/ml)<\/em><\/span><\/p>\n<p>Las colonias de E. coli\u00a0expuestas a 900 \u03bcg\/mL de la formulaci\u00f3n fitog\u00e9nica de Ventar D fueron m\u00e1s peque\u00f1as que las colonias de control.<em> A 1250 \u03bcg \/ ml, se detectaron menos colonias, y a 2500 \u03bcg \/ ml, ya no se pod\u00eda ver el crecimiento.<\/em><\/p>\n<p>Las colonias de salmonela mostraron una imagen similar; sin embargo, la reducci\u00f3n se pudo ver a partir de una concentraci\u00f3n de 1.250 \u03bcg\/ml de Ventar D en adelante (imagen 2).<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"wp-image-101149 size-full aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to.jpg\" alt=\"\" width=\"600\" height=\"403\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to.jpg 600w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-300x202.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-150x101.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-120x81.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-36x24.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-225x151.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-80x54.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-48x32.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-64x43.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-28x19.jpg 28w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><em><span style=\"font-size: 10pt;\">Figura 2: Salmonella ent\u00e9rica expuesta a diferentes concentraciones de Ventar D (fila superior de izquierda a derecha: control 0 \u03bcg\/ml, 500 \u03bcg\/ml, 900 \u03bcg\/ml; fila inferior de izquierda a derecha: 1250 \u03bcg\/ml y 2500 \u03bcg\/ml)<\/span><\/em><\/p>\n<h2>Prueba 2: Las fitomol\u00e9culas inhiben Clostridium perfringens sin afectar el crecimiento de los lactobacilos<\/h2>\n<p>En este ensayo, las bacterias (<em>Clostridium perfringens, Lactobacillus agilis S73, y Lactobacillus plantarum<\/em>) se cultivaron en condiciones favorables (MCR, 37\u00b0C, anaerobio para Clostr. perfr., y MRS, 37\u00b0C, 5 % de CO2 para Lactobacilos) y se expusieron a diferentes concentraciones de Ventar D (<em>0 \u03bcg\/ml \u2013 control, 500 \u03bcg\/ml, 750 \u03bcg\/ml y\u00a01000 \u03bcg\/ml).<\/em><\/p>\n<p>Los resultados se muestran en las figuras 3a-d.<\/p>\n<div class=\"row postid-101141-row\">\n<div class=\"vc_col-sm-3\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-101181 aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a.jpg 260w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-130x150.jpg 130w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-104x120.jpg 104w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-31x36.jpg 31w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-195x225.jpg 195w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-69x80.jpg 69w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-42x48.jpg 42w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-55x64.jpg 55w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-24x28.jpg 24w\" sizes=\"(max-width: 260px) 100vw, 260px\" \/><em><span style=\"font-size: 10pt;\">Figure 3a: control, 0 \u00b5g\/ml<\/span><\/em><\/p>\n<\/div>\n<div class=\"vc_col-sm-3\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-101213 aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b.jpg 260w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-130x150.jpg 130w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-104x120.jpg 104w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-31x36.jpg 31w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-195x225.jpg 195w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-69x80.jpg 69w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-42x48.jpg 42w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-55x64.jpg 55w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-24x28.jpg 24w\" sizes=\"(max-width: 260px) 100vw, 260px\" \/><em><span style=\"font-size: 10pt;\">Figure 3b: 500 \u00b5g\/ml<\/span><\/em><\/p>\n<\/div>\n<div class=\"vc_col-sm-3\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-101245 aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c.jpg 260w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-130x150.jpg 130w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-104x120.jpg 104w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-31x36.jpg 31w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-195x225.jpg 195w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-69x80.jpg 69w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-42x48.jpg 42w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-55x64.jpg 55w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-24x28.jpg 24w\" sizes=\"(max-width: 260px) 100vw, 260px\" \/><em><span style=\"font-size: 10pt;\">Figure 3c: 750 \u00b5g\/ml<\/span><\/em><\/p>\n<\/div>\n<div class=\"vc_col-sm-3\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"size-full wp-image-101277 aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d.jpg 260w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-130x150.jpg 130w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-104x120.jpg 104w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-31x36.jpg 31w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-195x225.jpg 195w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-69x80.jpg 69w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-42x48.jpg 42w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-55x64.jpg 55w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-24x28.jpg 24w\" sizes=\"(max-width: 260px) 100vw, 260px\" \/><em><span style=\"font-size: 10pt;\">Figure 3d: 1000 \u00b5g\/m<\/span><\/em><\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>En el caso de <em>Clostridium perfringens<\/em>, se pudo observar una reducci\u00f3n significativa de colonias a una concentraci\u00f3n de 500 \u03bcg\/ml de Ventar D. A 750 \u03bcg\/ml, solo quedaban unas pocas colonias. A una concentraci\u00f3n de Ventar D de 1000 \u03bcg\/ml, Clostridium perfringens ya no pod\u00eda crecer.<\/p>\n<p>En contraste con <em>Clostridium<\/em>, los <em>Lactobacilos<\/em> mostraron una imagen diferente: solo a la concentraci\u00f3n m\u00e1s alta (1250 \u03bcg \/ ml de Ventar D), Lactobacillus plantarum y Lactobacillus agilis S73 mostraron una ligera reducci\u00f3n del crecimiento (figuras 4 y 5).<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter wp-image-101341 size-full\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4.jpg\" alt=\"\" width=\"600\" height=\"305\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4.jpg 600w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-300x153.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-150x76.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-120x61.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-36x18.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-225x114.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-80x41.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-48x24.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-64x33.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-28x14.jpg 28w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><em><span style=\"font-size: 10pt;\">Figura 4: Lactobacillus plantarum expuesto a 0 (izquierda) y 1250 \u03bcg\/ml (derecha) de Ventar D<\/span><\/em><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter wp-image-101373 size-full\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5.jpg\" alt=\"\" width=\"600\" height=\"292\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5.jpg 600w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-300x146.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-150x73.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-120x58.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-36x18.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-225x110.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-80x39.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-48x23.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-64x31.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-28x14.jpg 28w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><em><span style=\"font-size: 10pt;\">Figura 5: Lactobacillus agilis S73 expuesto a 0 (izquierda) y 1250 \u03bcg\/ml (derecha) de Ventar D<\/span><\/em><\/p>\n<h2>Mejorar la salud intestinal al influir positivamente en la flora intestinal<\/h2>\n<p>Los experimentos muestran que incluso a concentraciones m\u00e1s bajas, las fitomol\u00e9culas perjudican el crecimiento de bacterias da\u00f1inas sin afectar a las beneficiosas. Los productos a base de fitomol\u00e9culas pueden considerarse una herramienta valiosa para controlar pat\u00f3genos relevantes en aves de corral e influir positivamente en la composici\u00f3n de la microflora.<\/p>\n<p>La mejor salud intestinal resultante es la mejor condici\u00f3n previa para reducir los antibi\u00f3ticos en la producci\u00f3n animal.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Por\u00a0el Dr. Inge Heinzl, Editora, EW Nutrition Desde el d\u00eda 1, los animales j\u00f3venes se enfrentan a los pat\u00f3genos de su entorno. Los alimentos y los ingredientes de los alimentos tambi\u00e9n aumentan significativamente la exposici\u00f3n a los microbios. Este art\u00edculo analizar\u00e1 de cerca tres bacterias cr\u00edticas en la producci\u00f3n av\u00edcola. Los ensayos de productos a&#8230;<\/p>\n","protected":false},"author":5,"featured_media":101442,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8455,9175],"tags":[8462],"class_list":["post-196377","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aves-de-corral","category-phytomolecules-es","tag-phytomolecules-es"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Modulaci\u00f3n eficiente del microbioma con fitomol\u00e9culas - EW Nutrition<\/title>\n<meta name=\"description\" content=\"Trials with a blend of selected phytomolecules showed an inhibiting effect on the poultry-critical bacteria E. coli, salmonella, and clostridium perfringens with simultaneously sparing the beneficial lactobacilli.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ew-nutrition.com\/es\/pushing-microbiome-in-right-direction-phytomolecules\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modulaci\u00f3n eficiente del microbioma con fitomol\u00e9culas\" \/>\n<meta property=\"og:description\" content=\"Trials with a blend of selected phytomolecules showed an inhibiting effect on the poultry-critical bacteria E. coli, salmonella, and clostridium perfringens with simultaneously sparing the beneficial lactobacilli.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ew-nutrition.com\/es\/pushing-microbiome-in-right-direction-phytomolecules\/\" \/>\n<meta property=\"og:site_name\" content=\"EW Nutrition\" \/>\n<meta property=\"article:published_time\" content=\"2022-07-06T06:25:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-11T12:08:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/featured-images\/gut-bacteria.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"518\" \/>\n\t<meta property=\"og:image:height\" content=\"574\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"EW Nutrition\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@EWNutritionGmbH\" \/>\n<meta name=\"twitter:site\" content=\"@EWNutritionGmbH\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"EW Nutrition\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Modulaci\u00f3n eficiente del microbioma con fitomol\u00e9culas - 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