{"id":76307,"date":"2021-06-08T12:40:51","date_gmt":"2021-06-08T10:40:51","guid":{"rendered":"https:\/\/ew-nutrition.com\/effective-solutions-poultry-gut-health\/"},"modified":"2022-09-21T08:08:39","modified_gmt":"2022-09-21T06:08:39","slug":"effective-solutions-poultry-gut-health","status":"publish","type":"post","link":"https:\/\/ew-nutrition.com\/en-uk\/effective-solutions-poultry-gut-health\/","title":{"rendered":"8 Effective Solutions to Optimize Poultry Gut Health"},"content":{"rendered":"<p>by<strong> Dr. Ajay Bhoyar<\/strong>, Global Technical Manager \u2013 Poultry, EW Nutrition<\/p>\n<p>&nbsp;<\/p>\n<p>Necessity, goes the saying, is the mother of invention. No wonder, then, that necessity is driving innovation in the poultry industry. \u00a0A few distinct such drivers of change stand out:<\/p>\n<p><strong>Genetic improvements<\/strong>: Significant genetic improvements have consistently increased the production performance of breeders, as well as commercial broilers and layers. The genetically improved breeds demand improved nutrition and management practices.<\/p>\n<p><strong>Feed ingredient prices\/availability<\/strong>: Corn and soybean meal are the main feed ingredients in poultry feed. Consequently any fluctuations in their prices have a high impact on the cost of production of eggs and meat. During the short span of the last 5 years, US corn and soybean meal prices <span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/en-uk\/4-ways-to-cope-increased-feed-prices\/\" target=\"_blank\" rel=\"noopener\">have increased<\/a><\/span> by around 54% and 68%, respectively. The optimum utilization of available feed ingredients and improvements in nutrient availability continue to be the key areas of interest for the poultry industry.<\/p>\n<p><strong>Consumer preference and regulatory changes<\/strong>: In certain geographies, these changes have resulted into 3 major trends in the poultry industry: antibiotics reduction (ABR), cage-free rearing, and food safety. The trend in the production and consumption of antibiotic-free meat products is growing faster than ever across the globe.<\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-73055\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2.jpg\" alt=\"\" width=\"958\" height=\"640\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2.jpg 1920w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-300x200.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-150x100.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-120x80.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-36x24.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-225x150.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-80x53.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-48x32.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-64x43.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-28x19.jpg 28w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/poultry-gut-health-2-807x539.jpg 807w\" sizes=\"(max-width: 958px) 100vw, 958px\" \/><\/p>\n<h2><strong>Antibiotics reduction (ABR): a key global trend<\/strong><\/h2>\n<p>Apart from veterinary use, antibiotics are used as feed additives \u2014antibiotic growth promoters (AGP) in animal production. Alarming levels of resistance to antibiotics have been reported in countries of all income levels, with the result that common diseases are becoming untreatable, and life-saving medical procedures riskier to perform.\u00a0 Misuse and overuse of antimicrobials are the main drivers in the development of drug-resistant pathogens. (WHO\/ https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antimicrobial-resistance )<\/p>\n<p>Antibiotic-free chicken production has gained a lot of momentum in the recent past. Over the past years, consumer preferences in the US resulted in a significant increase in the production of antibiotics-free (ABF) broiler chicken meat. In effect, the number of birds produced in \u201cno antibiotics ever\u201d (NAE) programs in the U.S. today is now at more than 50 percent (Poultry Health Today, 2019).<\/p>\n<p>The reduction of antibiotic use poses some challenges to poultry producers. Apart from increased capital investment for modifications in <span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/en-uk\/moisture-optimization-feed-quality-mill-efficiency\/\" target=\"_blank\" rel=\"noopener\">feed mills<\/a><\/span> and farms, increase in feed additive cost, the main challenge due to the removal of AGPs from feed can be the reduced production performance of poultry, mainly due to increased gut health issues.<\/p>\n<h4><strong>Good gut health is a must for profitable production<\/strong><\/h4>\n<p>\u201cThe intestinal health of poultry has broad implications for the systemic health of birds, animal welfare, the production efficiency of flocks, food safety, and environmental impact,\u201d state Oviedo-Rond\u00f3n (2019). The main challenges for ABF chicken or turkey production fall under the same heading of gut health, in particular the prevention and control of coccidiosis and necrotic enteritis (Cervantes, 2015).<\/p>\n<h2><strong>What are the most effective ways to mitigate gut health challenges?<\/strong><\/h2>\n<p>Depending on specific production needs and challenges, various technologies are used by the poultry producers to address gut health issues. Some of the most commonly used innovative technologies include:<\/p>\n<h4><strong>Dietary Fibers (DF)<\/strong><\/h4>\n<p>Scientists have found that DF have an enormous impact on the gastrointestinal tract (GIT) development, digestive physiology, including nutrient digestion, fermentation, and absorption processes of poultry (Jha &amp; Mishra, 2021).<\/p>\n<p><img decoding=\"async\" class=\" wp-image-73184 alignleft\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1.jpg\" alt=\"\" width=\"551\" height=\"368\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1.jpg 1280w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-300x200.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-150x100.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-120x80.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-36x24.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-225x150.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-80x53.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-48x32.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-64x43.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-28x19.jpg 28w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/feed-1-809x539.jpg 809w\" sizes=\"(max-width: 551px) 100vw, 551px\" \/>The water-insoluble fibers are seen as functional nutrients, as they can escape digestion and modulate nutrient digestion: \u201cA moderate level of insoluble fiber in poultry diets may increase chyme retention time in the upper part of the GIT, stimulating gizzard development and endogenous enzyme production, improving the digestibility of starch, lipids, and other dietary components\u201d (Mateos et.al. 2012). The insoluble DF, when used in amounts between 3\u20135% in the diet, could have significant effects on intestinal development and nutrient digestibility.<\/p>\n<p>Dietary fibers influence the development of the gizzard in poultry birds. \u00a0A well-developed gizzard is a must for good gut health. Jim\u00e9nez-Moreno &amp; Mateos (2012) noted that the coarse fiber particles are selectively retained in the gizzard, that ensures a complete grinding and a well-regulated feed flow and secretion of digestive juices, and regulates GIT motility &amp; feed intake. The inclusion of insoluble fibers in adequate amounts improves the gizzard function and stimulates HCl production in the proventriculus. Thus it can help in the control of gut pathogens.<\/p>\n<h4><strong>Probiotics and prebiotics<\/strong><\/h4>\n<p>Probiotics and prebiotics have drawn considerable attention as alternatives to antibiotics in animal feeds. Supplementing diets with probiotics and prebiotics is a significant factor contributing to modified intestinal microflora, which, in turn, may effectively influence the birds\u2019 growth performance and health (Yang et al. 2009).<\/p>\n<p>Probiotics introduce desirable microorganisms into the intestinal tract through the diet (feed or water). They consist of live bacteria, fungi, or yeasts that positively contribute to the gastrointestinal flora. As such, they are important for a well-formed and well-maintained digestive system, and are indirectly essential to growth performance and to the overall health of animals in general. Probiotic supplementation could have the following effects, as stated by Jha et al:<\/p>\n<ul class=\"list-black\">\n<li>modification of the intestinal microbiota<\/li>\n<li>stimulation of the immune system<\/li>\n<li>reduction in inflammatory reactions<\/li>\n<li>prevention of pathogen colonization<\/li>\n<li>enhancement of growth performance<\/li>\n<li>alteration of the ileal digestibility and total tract apparent digestibility coefficient<\/li>\n<li>decrease in ammonia and urea excretion (Jha et.al., 2020)<\/li>\n<\/ul>\n<p>Probiotics can be used not just in feed and drinking water, but also in spray solutions applied to day-old chicks either in the hatchery or immediately after placement in the brooding house. This way, the beneficial microorganisms can enter the intestine earlier than through other methods (known as early seeding).<\/p>\n<p>Prebiotics are also a means of increasing the beneficial bacteria in the poultry gut microbiota. Prebiotics like mannan-oligosaccharides (MOS), inulin and its hydrolysate (fructooligosaccharides: FOS), as well as other prebiotics are important contributors to the modulation of the intestinal microflora and stimulating a potential immune response, as well as stimulating the development of beneficial microorganisms. Prebiotics can also help reduce pathogen colonization in the GIT.<\/p>\n<h3><strong>Feed enzymes<\/strong><\/h3>\n<p>The role of feed enzymes in promoting the efficiency of nutrient utilization is well recognized. Recent estimates (Adeola &amp; Cowieson, 2011) indicate that feed enzymes saved the global feed market an estimated US $3\u20135 billion per year. Feed Enzymes can also have a positive impact on gut health.<\/p>\n<p>Among the beneficial effects of feed enzymes are:<\/p>\n<ul class=\"list-black\">\n<li>Inactivating anti-nutrients in the feed ingredients<\/li>\n<li>Unlocking nutrients otherwise unavailable to birds (e.g. Phosphorus from phytic acid)<\/li>\n<li>Reducing harmful microbial proliferation, depriving detrimental microorganisms of nutrients<\/li>\n<li>Reducing the undigestible components of feed, the viscosity of digesta, or the irritation to the gut\u00a0mucosa that causes inflammation.<\/li>\n<\/ul>\n<p>Enzymes also generate metabolites that promote microbial diversity, which helps to maintain gut ecosystems that are more stable and more likely to inhibit pathogen proliferation (Bedford, 1995; Kiarie et al., 2013). Feed enzymes are heat-sensitive and tend to lose their activity potential during pelleted feed manufacturing. There has been a significant interest in the application of intrinsically heat stable enzymes for more efficient action. Apart from coated feed enzymes, the post pellet liquid application (PPLA) of feed enzymes has increased in the recent past.<\/p>\n<h3><strong>Toxin binders &amp; antioxidants<\/strong><\/h3>\n<p>Intestinal health problems can often be preempted, especially in poultry companies with ABF production programs, by mitigating the danger of mycotoxins in feedstuffs and rancid fats (Murugesan et al., 2015; Grenier and Applegate, 2013). <span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/en-uk\/a-complex-battlefield-mycotoxins-in-the-gastrointestinal-tract\/\" target=\"_blank\" rel=\"noopener\">Mycotoxins<\/a> <\/span>can compromise several key functions of GIT. This often results in decreased nutrient absorption (by decreasing the available surface area), modulation of nutrient transporters, and loss of barrier function (Grenier and Applegate, 2013). Some mycotoxins \u201cencourage\u201d the persistence of intestinal pathogens and thus enhance the possibility of intestinal inflammation.<\/p>\n<p><img decoding=\"async\" class=\" wp-image-73120 alignright\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg.jpg\" alt=\"\" width=\"394\" height=\"262\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg.jpg 1920w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-300x200.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-150x100.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-120x80.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-36x24.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-225x150.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-80x53.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-48x32.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-64x43.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-28x19.jpg 28w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-msg-810x539.jpg 810w\" sizes=\"(max-width: 394px) 100vw, 394px\" \/><\/p>\n<p>Rancid fats and oils have been linked to the pathogenesis of enteric diseases (Hoerr, 1998; Butcher and Miles, 2000; Collet, 2005). The oxidation of oils and fats negatively impacts the energy content of these ingredients. The addition of feed antioxidants during the rendering process\/ blending of fats and oils, and proper storage and transport before final use in feed can control rancidity in oils and fats. Proper fat storage conditions in tanks and transportation lines should be constantly monitored to prevent the development of rancidity in the feed mill. Antioxidants and mycotoxin binders can reduce the effects of mycotoxins and peroxide, especially, but not only, in ABF programs (Yegani and Korver, 2008).<\/p>\n<h3><strong>Organic acids<\/strong><\/h3>\n<p>Organic acids are compounds with acidic properties that occur naturally and include carbon. As the digestive process includes microbial fermentation, beneficial bacteria which naturally reside in the crop, intestines, and ceca produce such organic acids (Huyghebaert et.al. 2010). The inclusion of organic acids in poultry diets can improve gut health, increase endogenous digestive enzyme secretion and activity, and improve nutrient digestibility. Thus they generally contribute to the overall gut health of the animal.<\/p>\n<p>The inclusion of organic acids in feed can help not only decontaminate feed but also have the potential to reduce enteric pathogens in poultry. The acids can cross the bacterial cell wall and disrupt the normal actions of certain types of bacteria, including Salmonella spp, E. coli, Clostridia spp, Listeria spp. and some coliforms.<\/p>\n<p>Organic acids are also used in drinking water to help lower the microbial count. This can be achieved by lowering the pH of water and by the prevention\/removal of biofilms in the water lines.<\/p>\n<p>However, organic acids should be included in the feed or water with caution. The limitations for use of organic acids in animal production can be:<\/p>\n<ul class=\"list-black\">\n<li>Bacterial resistance to organic acids over long-term use<\/li>\n<li>Adverse effect on feed palatability, leading to feed refusal<\/li>\n<li>Organic acids are corrosive in nature and can damage poultry equipment<\/li>\n<li>Buffering capacity of dietary ingredients can impact efficacy<\/li>\n<\/ul>\n<h3><strong>Essential oils\/Phytomolecules<\/strong><\/h3>\n<p>Essential oils (EOs) are raw extracts from plants (herbs, flowers, leaves, roots, fruit etc.). The beneficial effects of EOs include appetite stimulation, improvement of enzyme secretion related to food digestion, and immune response activation (Krishan and Narang, 2014)<\/p>\n<p>EOs are an unpurified mix of different <span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/en-uk\/poultry-health-and-welfare-phytomolecules-for-poultry-diets\/\" target=\"_blank\" rel=\"noopener\">phytomolecules<\/a><\/span>. The raw extract from oregano is a mix of various phytomolecules (terpenoids) like carvacrol, thymol, and p-cymene. Carvacrol, for instance, is a monoterpinoid found in various plants such as oregano or thyme. A phytomolecule is one active compound.<\/p>\n<p><img decoding=\"async\" class=\"wp-image-73152 alignleft\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo.jpg\" alt=\"\" width=\"450\" height=\"290\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo.jpg 1280w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-300x193.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-150x96.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-120x77.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-36x23.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-225x145.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-80x51.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-48x31.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-64x41.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-28x18.jpg 28w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-activo-838x539.jpg 838w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/p>\n<p>These botanicals have received increased attention as possible growth performance enhancers for animals in the last decade because of their beneficial influence on lipid metabolism, as well as their antimicrobial and antioxidant properties (Botsoglou et al., 2002), their ability to stimulate digestion (Hernandez et al., 2004), their immune-enhancing activity, and anti-inflammatory potential (Acamovic and Brooker, 2005). Many studies have reported on the supplementation of poultry diets with essential oils that enhanced weight gain, improved carcass quality, and reduced mortality rates (Williams and Losa, 2001). The use of specific EO blends can be effective in reducing the colonization and proliferation of <em>Clostridium perfringens<\/em> and controlling <em>coccidia<\/em> infections. Consequently, it may also help reduce <a href=\"https:\/\/ew-nutrition.com\/en-uk\/necrotic-enteritis-the-complete-overview\/\" target=\"_blank\" rel=\"noopener\"><span style=\"text-decoration: underline;\">necrotic enteritis<\/span><\/a> (Guo et al., 2004; Mitsch et al., 2004; Oviedo-Rond\u00f3n et al., 2005, 2006a, 2010).<\/p>\n<h4><strong>Mode of action of phytomolecules<\/strong><\/h4>\n<p>The gut health optimizing mode of action of phytomolecule-based preparations like Activo\u00ae (EW Nutrition) can be described as follows:<\/p>\n<p><img decoding=\"async\" class=\" wp-image-73280 alignnone\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1.png\" alt=\"\" width=\"606\" height=\"322\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1.png 640w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-300x159.png 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-150x80.png 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-120x64.png 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-36x19.png 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-225x120.png 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-80x43.png 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-48x26.png 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-64x34.png 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-moa-activo-1-28x15.png 28w\" sizes=\"(max-width: 606px) 100vw, 606px\" \/><\/p>\n<h5><strong>Digestive<\/strong><\/h5>\n<p>The digestive properties increase the secretion of digestive enzymes and enhance gut motility. A \u201csignificant increase in pancreatic trypsin, amylase, and maltase activities in broilers fed different blends of commercial essential oils\u201d has been reported as well (Jang et al., 2007). The essential oils in carvacrol, for instance, have positive effects on growth performance and the intestinal barrier function of broilers. They were also able to support repairing the intestinal damage caused by lipopolysaccharides (Liu et al. 2020).<\/p>\n<h5><strong>Antimicrobial<\/strong><\/h5>\n<p>The <a href=\"https:\/\/ew-nutrition.com\/en-uk\/animal-nutrition\/challenges\/antibiotic-reduction\/\">antimicrobial properties<\/a> of phytomolecules can impede the growth of potential pathogens. Thymol, eugenol, and carvacrol have been shown to have \u201csynergistic or additive antimicrobial effects when combined at lower concentrations\u201d (Bassol\u00e9 and Juliani, 2012). In <em>in vivo<\/em> studies, essential oils used either individually or in combination \u201chave shown clear growth inhibition of Clostridium perfringens and E. coli in the hindgut and ameliorated intestinal lesions and weight loss than the challenged control birds\u201d (Jamroz et al., 2006, Jerzsele et al., 2012, Mitsch et al., 2004).<\/p>\n<p>One well-known mechanism of antibacterial activity is linked to the phytomolecules\u2019 \u00a0hydrophobic nature. This characteristic helps disrupt the permeability of cell membranes and cell homeostasis. The consequence of this disruption is the loss of cellular components, influx of other substances, or even cell death (Brenes and Roura, 2010, Sol\u00f3rzano-Santos and Miranda-Novales, 2012, Windisch et al., 2008, O&#8217;Bryan et al., 2015).<\/p>\n<h5><strong>Antioxidant<\/strong><\/h5>\n<p>The antioxidant properties at the gut level prevent free radical formation and oxidative stress. Thymol and carvacrol have been shown to inhibit lipid peroxidation (Hashemipour et.al. 2013), a mechanism leading to the oxidative destruction of cellular membranes (Rhee et al., 1996). This destruction can ultimately lead to cell death and to the production of toxic and reactive aldehyde metabolites, known as free radicals. Among these free radicals, malondialdehyde (MDA) as a final product of lipid peroxidation has often been used for determining oxidative damage (Jensen et al., 1997). \u00a0Thymol and carvacrol both have strong antioxidant activity (Yanishlieva et al., 1999). Oregano \u201cadded in doses of 50 to 100 mg\/kg to the diet of chickens exerted an antioxidant effect in the broiler tissues\u201d (Botsoglou et al., 2002).<\/p>\n<p>It has also been suggested that chicken body oxidative balance can benefit from essential oils. Karadas et al. (2014) fed a blend of carvacrol, cinnamaldehyde, and capsicum oleoresin to Ross 308 broilers, and found a significant increase in the hepatic concentration of carotenoids and coenzyme Q10 at d 21 of age.<\/p>\n<p>Essential oils, or phytomolecules, are highly volatile substances and are susceptible to changes caused by external factors such as light, oxygen, and temperature, in addition to being prone to evaporating. They need to be protected\/micro-encapsulated during the process of feed manufacturing. The advantages of matrix encapsulation include<\/p>\n<ul class=\"list-black\">\n<li>a slow and gradual release of active ingredients in the digestive tract<\/li>\n<li>protection of phytomolecules from oxidation and other harsh conditions during feed processing<\/li>\n<li>prevention of any negative effects on palatability of feed<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"wp-image-73216 alignnone\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation.png\" alt=\"\" width=\"778\" height=\"385\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation.png 1920w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-300x149.png 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-150x74.png 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-120x59.png 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-36x18.png 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-225x111.png 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-80x40.png 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-48x24.png 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-64x32.png 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-28x14.png 28w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/content-images\/6-effective-microencapsulation-920x456.png 920w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><\/p>\n<p><span style=\"font-size: 10pt;\"><em>Above: Micro-encapsulation protecting phytomolecules in feed processing<\/em><\/span><\/p>\n<p>Apart from use in feed, the liquid phytomolecules preparations for drinking water use can prove to be beneficial in preventing and controling losses during challenging periods of the birds\u2019 life (feed change, handling, environmental stress, etc.).\u00a0 The liquid preparations have the potential to reduce morbidity and mortality in poultry houses and thus the use therapeutic antibiotics. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/en-uk\/necrotic-enteritis-ab-free\/\" target=\"_blank\" rel=\"noopener\">Barrios et al.<\/a><\/span> (2021) suggested that Activo and Activo Liquid may ameliorate the impact of Necrotic Enteritis on broilers and further hypothesized that the effects of Activo Liquid were particularly important in improving overall mortality.<\/p>\n<h3><strong>Conclusion<\/strong><\/h3>\n<p>The prevailing driving forces of the market will continue to challenge the dynamic poultry industry. Still, gut health challenges in ABF poultry production can be alleviated with multifactorial approaches, including changes in nutrition and improved management practices. Innovative feed additive technologies have contributed to reducing production losses triggered by the removal of AGPs in poultry production.<\/p>\n<p>Essential oils\/phytomolecules are one such promising technology, with proven benefits in terms of the production performance of poultry. Phytomolecules are generally recognized as safe and are commonly used in the food industry. Some of the phytomolecules combinations have multiple modes of action, supporting an efficient and sustainable reduction in antibiotics use in poultry production.<\/p>\n<p>To make ABF programs successful, however, more attention needs to be given to the whole production system, not only to feed, feed additives or control of a few enteric pathogens. Housing, management, water quality and <span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/en-uk\/5-principles-to-consider-when-designing-biosecurity-programmes\/\" target=\"_blank\" rel=\"noopener\">biosecurity<\/a><\/span> at both breeder and grow-out levels are critical in ABF production.<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<h6><span style=\"font-size: 18pt;\"><span style=\"font-size: 14pt;\"><strong>References<\/strong><\/span><br \/>\n<\/span><\/h6>\n<p><span style=\"font-size: 10pt;\">Acamovic, T., and J. D. Brooker. 2005. Biochemistry of plant secondary metabolites and their effects in animals. Proc. Nutr. 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No wonder, then, that necessity is driving innovation in the poultry industry. \u00a0A few distinct such drivers of change stand out: Genetic improvements: Significant genetic improvements have consistently increased the production performance of breeders,&#8230;<\/p>\n","protected":false},"author":5,"featured_media":73099,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8039,7670,8030],"tags":[8035,8041],"class_list":["post-76307","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antibiotic-reduction-en-uk-2","category-gut-health-en-uk","category-poultry-en-uk","tag-gut-health-en-uk-2","tag-poultry-en-uk-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>8 Effective Solutions to Optimize Poultry Gut Health - 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