{"id":146265,"date":"2021-04-23T07:33:04","date_gmt":"2021-04-23T05:33:04","guid":{"rendered":"https:\/\/ew-nutrition.com\/phytomolecules-for-pig-antibiotic-reduction\/"},"modified":"2022-09-21T08:11:29","modified_gmt":"2022-09-21T06:11:29","slug":"phytomolecules-for-pig-antibiotic-reduction","status":"publish","type":"post","link":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/","title":{"rendered":"How phytomolecules support antibiotic reduction in pig production"},"content":{"rendered":"<div class=\"intro\" style=\"text-align: justify;\">\n<p><em><span style=\"font-size: 10pt;\">by\u00a0<b> Merideth Parke<\/b>, Regional Technical Manager, EW Nutrition<\/span><\/em><\/p>\n<p><strong>To contain and reverse <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.wur.nl\/upload_mm\/7\/b\/0\/5e568649-c674-420e-a2ca-acc8ca56f016_Maran%202018.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">antimicrobial resistance<\/a><\/span>, consumers and government regulators expect changes in pork production with the clear goal to reduce antibiotic use.\u00a0<\/strong><strong>For healthy, profitable pig production with simultaneous antibiotic reduction, a <a href=\"https:\/\/ec.europa.eu\/eip\/agriculture\/en\/european-innovation-partnership-agricultural\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline;\">holistic strategy<\/span><\/a> is required: refocusing human attitudes and habits, optimal pig health and welfare, and applying potential antibiotic alternatives.<\/strong><\/p>\n<figure id=\"attachment_85880\" aria-describedby=\"caption-attachment-85880\" style=\"width: 1080px\" class=\"wp-caption alignnone\"><img decoding=\"async\" class=\"wp-image-85880 size-full\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated.jpg\" alt=\"\" width=\"1080\" height=\"420\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated.jpg 1080w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-300x117.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-150x58.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-120x47.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-36x14.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-225x88.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-80x31.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-48x19.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-64x25.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-28x11.jpg 28w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/corn_contaminated-920x358.jpg 920w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/><figcaption id=\"caption-attachment-85880\" class=\"wp-caption-text\">Corn is often contaminated with Aspergillus fungi that can produce poisonous mycotoxins<\/figcaption><\/figure>\n<\/div>\n<h1>Pig producers need to manage pathogenic pressure while reducing antibiotics<\/h1>\n<p>Intensive pig production has stress points associated with essential husbandry procedures such as weaning, health interventions, and dietary modifications. Stress is widely accepted to have a negative impact on immune system effectiveness, enhancing opportunities for pathogenic bacteria to invade at a local or systemic level. The gastrointestinal and respiratory systems are highly susceptible to developing disease as a result of these combined factors. Interventions such as antibiotics are commonly implemented to reduce the impact of pathogens and manage pig health. Processes that minimize the number of pathogens in the environment are the foundation for a successful antibiotic reduction plan. The challenge is to smartly combine strategies to keep the gastrointestinal and <a href=\"https:\/\/ew-nutrition.com\/healthfood\/application-areas\/respiratory-care\/\">respiratory tract<\/a> intact and robust.<\/p>\n<p>Phytomolecules, the specific active defense compounds found in plants, have been identified as capable of enhancing pig health through antimicrobial (<a href=\"https:\/\/doi.org\/10.1016\/s0378-8741(01)00384-1\"><span style=\"text-decoration: underline;\">Cimanga et al., 2002<\/span><\/a>, <a href=\"https:\/\/doi.org\/10.1002\/ffj.1967\"><span style=\"text-decoration: underline;\">Franz et al., 2010<\/span><\/a>), antioxidative (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1016\/j.foodchem.2004.12.004\">Katalinic et al., 2006<\/a><\/span>, <a href=\"https:\/\/www.agriculturejournals.cz\/publicFiles\/39925.pdf\"><span style=\"text-decoration: underline;\">Damjanovic-Vratnica et al., 2007<\/span><\/a>, <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1002\/jsfa.980\">Lee et al., 2011<\/a><\/span>), digestion-stimulating and immune-supportive functions. As many thousands of phytomolecules exist,\u00a0 laboratory research has focused on identifying those with the capability of microbial management, facilitating the end goal of reducing the reliance on antibiotics for pig health and welfare and the production of safe pork (<a href=\"https:\/\/doi.org\/10.1016\/j.aninu.2018.01.005\"><span style=\"text-decoration: underline;\">Zhai et al., 2018<\/span><\/a>).<\/p>\n<h2>Which roles can phytomolecules play in reducing antibiotics?<\/h2>\n<p>The gastrointestinal tract benefits from applying phytomolecules such as capsaicin, carvacrol, and cinnamaldehyde, as they:<\/p>\n<ul class=\"list-black\">\n<li>support a balanced and stable biome,<\/li>\n<li>prevent dysbiosis, maintain tight junction integrity (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1111\/jpn.12944\">Liu et al., 2018<\/a><\/span>),<\/li>\n<li>increase secretion of digestive enzymes, and<\/li>\n<li>enhance gut contractility (<a href=\"https:\/\/doi.org\/10.1016\/j.aninu.2018.01.005\"><span style=\"text-decoration: underline;\">Zhai et al., 201<\/span>8<\/a>).<\/li>\n<\/ul>\n<p>Pigs most susceptible and in need of phytomolecule <a href=\"https:\/\/ew-nutrition.com\/healthfood\/application-areas\/gastrointestinal-care\/\">gastrointestinal supportive actions<\/a> are piglets at weaning and pigs of all ages undergoing stress, pathogen challenges, and\/or dietary changes.<\/p>\n<p>Porcine respiratory disease is a complex multifactorial disorder. It frequently requires antibiotics to manage infection pressure and clinical disease to maintain pig health, welfare, and production performance. Causal pathogens may be transmitted by direct contact between pigs in saliva (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0215983\">Murase et al., 2018<\/a><\/span>) or bioaerosols (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1007\/s00203-019-01655-7\">LeBel et al., 2019<\/a><\/span>), via the nasal or oral cavities (inhalation directly into the airways and lungs), or via an unhealthy gut. Phytomolecules such as carvacrol and cinnamaldehyde have antimicrobial properties. Hence, they may help contain respiratory pathogens in their natural habitat (the upper respiratory tract) or during transit through the oronasal cavity and <a href=\"https:\/\/ew-nutrition.com\/en-uk\/a-complex-battlefield-mycotoxins-in-the-gastrointestinal-tract\/\">gastrointestinal tract<\/a> (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378113504002093\"><span style=\"text-decoration: underline;\">Swildens et al., 2004<\/span><\/a>, <a href=\"https:\/\/doi.org\/10.1002\/jsfa.980\"><span style=\"text-decoration: underline;\">Lee et al., 2001<\/span><\/a>).<\/p>\n<p>In addition to supporting the gastrointestinal and respiratory systems, phytomolecules such as menthol and 1,8-cineole have been shown to enhance the physical and adaptive immune systems in multiple species (<a href=\"https:\/\/www.researchgate.net\/publication\/318342501_18-cineole_An_Underappreciated_Anti-inflammatory_Therapeutic\"><span style=\"text-decoration: underline;\">Brown et al., 2017<\/span><\/a>, <span style=\"text-decoration: underline;\"><a href=\"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/full\/10.1111\/jam.12334\">Barbour et al., 2013<\/a><\/span>). When applied via drinking water, adherence to the oronasal mucosa facilitates the inhalation of the active phytomolecule compounds into the respiratory tract. There, they act as mucolytics, muscle relaxants, and enhancers of the mucociliary clearance mechanism (Bas\u0327er and Buchbauer, 2020). Phytomolecules have also been documented to positively influence the adaptive immune system, promoting both humoral and cell-mediated immune responses (<span style=\"text-decoration: underline;\"><a href=\"http:\/\/www.pvj.com.pk\/\">Awaad et al., 2010<\/a><\/span>, Gopi et al., 2014, <span style=\"text-decoration: underline;\"><a href=\"https:\/\/bmcimmunol.biomedcentral.com\/articles\/10.1186\/1471-2172-9-17\">Serafino et al., 2008<\/a><\/span>).<\/p>\n<h2>How phytomolecules feature in the holistic approach to antibiotic reduction<\/h2>\n<p>Antibiotic reduction programs positively enact social responsibility by reducing the risk to farmworkers of <a href=\"https:\/\/ew-nutrition.com\/en-uk\/animal-nutrition\/challenges\/antibiotic-reduction\/\">exposure to antimicrobial-resistant<\/a> bacteria. They also help maintain or increase efficiency in safe pork production \u2013 pork with minimal risk of antibiotic residues.<\/p>\n<p>Implementation of a successful health program with reduced antibiotic use will require:<\/p>\n<ul class=\"list-black\">\n<li>application of strict internal and external biosecurity processes;<\/li>\n<li>evaluation and monitoring of AMR bacteria;<\/li>\n<li>partnerships with specialist nutritionists to target a lifetime healthy gut biome; and<\/li>\n<li>phytomolecule-assisted health management (Figure 1).<\/li>\n<\/ul>\n<figure id=\"attachment_85848\" aria-describedby=\"caption-attachment-85848\" style=\"width: 1777px\" class=\"wp-caption alignnone\"><img decoding=\"async\" class=\"wp-image-85848 size-full\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article.jpg\" alt=\"\" width=\"1777\" height=\"488\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article.jpg 1777w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-300x82.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-150x41.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-120x33.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-36x10.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-225x62.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-80x22.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-48x13.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-64x18.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-28x8.jpg 28w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/art48__ac_pig_how-phytomolecules-support-antibiotic-reduction-in-pig-production_en\/figure-1-merideth-phytomolecules-article-920x253.jpg 920w\" sizes=\"(max-width: 1777px) 100vw, 1777px\" \/><figcaption id=\"caption-attachment-85848\" class=\"wp-caption-text\">Figure 1: The role of phytomolecules within EW Nutrition&#8217;s holistic Antibiotic Reduction program<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>A combination of <em>in vitro<\/em> and <em>in vivo<\/em> studies provides evidence that specific phytomolecules can support both enteric and respiratory systems through biome stabilisation and pathogen management (<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00253-020-10998-x\"><span style=\"text-decoration: underline;\">Bajabai et al., 2020<\/span><\/a>). Antimicrobial activity of thymol, carvacrol, and cinnamaldehyde has been reported against respiratory pathogens including <em>S. suis, A. pleuropneumoniae<\/em>, and<em> H. parasuis<\/em> (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1007\/s00203-019-01655-7\">LeBel et al., 2019<\/a><\/span>)<em>;<\/em> multi-drug resistant and ESBL bacteria (<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jf051922u\"><span style=\"text-decoration: underline;\">Bozin et al., 2006<\/span><\/a>); enteric pathogens including <em>E. coli<\/em>, <em>Salmonella enteritidis<\/em>, <em>Salmonella cholerasuis<\/em>, and<em> Salmonella typhimurium<\/em> (<span style=\"text-decoration: underline;\">Penalver et al., 2005<\/span>); <em>Clostridium<\/em> spp., <em>E. coli<\/em> spp., <em>Brachyspira hyodysenteriae <\/em>(<a href=\"https:\/\/doi.org\/10\/1292\/jvms.15-0341\"><span style=\"text-decoration: underline;\">Vande Maelle et al., 2015<\/span><\/a>); and <em>Lawsonia intracellularis<\/em> (<a href=\"https:\/\/doi.org\/10.1016\/j.prevetmed.2018.01.002\"><span style=\"text-decoration: underline;\">Draskovic et al., 2018<\/span><\/a>). These results have shown phytomolecules to be effective antimicrobial alternatives for incorporation into holistic pig health programs.<\/p>\n<p>Additionally, the inclusion of phytomolecules into pig production systems also enhances production performance by reducing the negative impact of stress on the pig and increasing the positive effects on gut health and nutrient utilization (<a href=\"https:\/\/doi.org\/10.1002\/ffj.1967\"><span style=\"text-decoration: underline;\">Franz et al., 2010<\/span><\/a>). Phytomolecules that directly impact digestive actions include capsaicin, which optimizes the production of digestive enzymes and increases serotonin for gut contraction maintenance and improved digesta mixing (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1016\/j.aninu.2018.01.005\">Zhai et al., 2018<\/a><\/span>). Cineol&#8217;s antioxidative activities provide support during times of stress (<a href=\"https:\/\/doi.org\/10.1016\/s0378-8741(01)00384-1\"><span style=\"text-decoration: underline;\">Cimanga et al., 2002<\/span><\/a>).<\/p>\n<h3>Phytomolecules are key to reducing antibiotics in pig production<\/h3>\n<p>The pig industry searches for alternatives to therapeutic, prophylactic, and growth-promoting antibiotic applications to keep available antibiotics effective for longer \u2013 and to address the social responsibility of mitigating AMR. This search for ways to produce safe pork has made it clear that only a combination of management and antibiotic alternatives can achieve these aligned goals.<\/p>\n<p>Biosecurity, hygiene, stress reduction, and husbandry and nutritional advances form the foundation for the strategic application of specific phytomolecules (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org?10\/1186\/s40104-015-004-5\">Zeng et al. 2016<\/a><\/span>). Supporting pig production and health, this complete holistic solution <a href=\"https:\/\/ec.europa.eu\/eip\/agriculture\/en\/european-innovation-partnership-agricultural\">(<span style=\"text-decoration: underline;\">EIP-AGRI<\/span>)<\/a> moves the pig industry into a future where antibiotic reduction or removal, with equivalent or increased production of safe pork, becomes a reality.<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<h4><strong><span style=\"font-size: 10pt;\">References<\/span><\/strong><\/h4>\n<p><span style=\"font-size: 10pt;\">Awaard M, Abdel-Alim G, Sayed K, Kawkab, Ahmed1 A, Nada A , Metwalli A, Alkhalaf A. &#8220;Immunostimulant effects of essential oils of peppermint and eucalyptus in chickens&#8221;. <em>Pakistan Veterinary Journal<\/em> (2010). 2:61-66. <span style=\"text-decoration: underline;\"><a href=\"http:\/\/www.pvj.com.pk\/\">http:\/\/www.pvj.com.pk\/<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Bajagai YS, Alsemgeest J, Moore RJ, Van TTH, Stanley D. &#8220;Phytogenic products, used as alternatives to antibiotic growth promoters, modify the intestinal microbiota derived from a range of production systems: an in vitro model&#8221;. <em>Applied Microbiology and Biotechnology<\/em> (2020). 104:10631-10640. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1007\/s00253-020-10998-x\">https:\/\/doi.org\/10.1007\/s00253-020-10998-x<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Barbour EK, Shaib H, Azhar E, Kumosani T, Iyer A, Harakey S, Damanhouri G, Chaudary A, Bragg RR. &#8220;Modulation by essential oil of vaccine response and production improvement in chicken challenged with velogenic Newcastle disease virus&#8221;. <em>Journal of Applied Microbiology<\/em> (2013). 115, 1278-1286. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi:10.1111\/jam.12334\">https:\/\/doi:10.1111\/jam.12334<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Biljana Damjanovic-Vratnica, Tatjana Dakov, Danijela Sukovic, Jovanka Damjanovic. &#8220;Antimicrobial effect of essential oil isolated from Eucalyptus globulus Labill&#8221; (2011). <em>Czech Journal of Food Science<\/em> 27(3):277-284. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.agriculturejournals.cz\/publicFiles\/39925.pdf\">https:\/\/www.agriculturejournals.cz\/publicFiles\/39925.pdf<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Bozin B, Mimica-Dukic N, Smin N, Anackov G. &#8220;Characterization of the volatile composition of essential oils of some Lamiaceae spices and the antimicrobial and antioxidant activities of the entire oils&#8221; <em>Journal of Agriculture and Food Chemicals<\/em> (2006). 54:1822-1828<span style=\"text-decoration: underline;\"> <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jf051922u\">https:\/\/pubs.acs.org\/doi\/10.1021\/jf051922u<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Brown SK, Garver WS, Orlando RA. &#8220;1,8-cineole: An Underappreciated Anti-inflammatory Therpeutic&#8221; <em>Journal of Biomolecular Research &amp;Therapeutics <\/em>(2017). 6:1 1-6\u00a0 <a href=\"https:\/\/doi:%2010.4172\/2167-7956.1000154\">https:\/\/doi: 10.4172\/2167-7956.1000154<\/a><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Cimanga K., Kambu K., Tona L., Apers S., De Bruyne T., Hermans N., Totte J., Pieters L., Vlietinck A.J. &#8220;Correlation between chemical composition and antibacterial activity of essential oils of some aromatic medicinal plants growing in the Democratic Republic of Congo&#8221;. <em>Journal of Ethnopharmacology<\/em> (2002) 79: 213\u2013220. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1016\/s0378-8741(01)00384-1\">https:\/\/doi.org\/10.1016\/s0378-8741(01)00384-1<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Draskovic V, Bosnjak-Neumuller J, Vasiljevic M, Petrujkic B, Aleksic N, Kukolj V, Stanimirovic Z. &#8220;Influence of phytogenic feed additive on Lawsonia intracellularis infection in pigs&#8221; <em>Preventative Veterinary Medicine <\/em>(2018). 151: 46-51 <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1016\/j.prevetmed.2018.01.002\">https:\/\/doi.org\/10.1016\/j.prevetmed.2018.01.002<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">European Innovation Partnership Agricultural Productivity and Sustainability (EIP-AGRI). <span style=\"text-decoration: underline;\"><a href=\"https:\/\/ec.europa.eu\/eip\/agriculture\/en\/european-innovation-partnership-agricultural\">https:\/\/ec.europa.eu\/eip\/agriculture\/en\/european-innovation-partnership-agricultural<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Franz C., Baser KHC, Windisch W. &#8220;Essential oils and aromatic plants in animal feeding-a European perspective. A review Flavour&#8221;. <em>Flavour and Fragrance Journal<\/em> (2010) 25:327-40. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1002\/ffj.1967\">https:\/\/doi.org\/10.1002\/ffj.1967<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Gopi M, Karthik K, Manjunathachar H, Tamilmahan P, Kesavan M, Dashprakash M, Balaraju B, Purushothaman M. &#8220;Essential oils as a feed additive in poultry nutrition&#8221;. <em>Advances in\u00a0 Animal and Veterinary Sciences<\/em> (2014) 1:17. \u00a0<span style=\"text-decoration: underline;\">https:\/\/doi.<a href=\"https:\/\/www.researchgate.net\/deref\/http%3A%2F%2Fdx.doi.org%2F10.14737%2Fjournal.aavs%2F2014.2.1.1.7?_sg%5B0%5D=rdcaxhgWzpdr9h14HlN8QjM5odPLZhX1RIB5qdg5LG2Faqf0tdvjTR8dJI9c1ulGoVVnbdDLoUTg5tS1uBO8iPemYg.9negh3YvVx2u4-vM698k3kEv7EYDQwnQDLdq8MBgJUvgtDjS4mU5KxZy9r59W9USS3aukmarM82rHXrqne3Urw\">10.14737\/journal.aavs\/2014.2.1.1.7<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Bas\u0327er, Kemal Hu\u0308snu\u0308 Can, and Gerhard Buchbauer. Handbook of Essential Oils Science, Technology, and Applications. Boca Raton: CRC Press, 2020.<\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Hengziao Zhai, Hong Liu, Shikui Wang, Jinlong Wu, Anna-Maria Kluenter. &#8220;Potential of essential oils for poultry and pigs.&#8221; <em>Animal Nutrition <\/em>4 (2018): 179-186. \u00a0<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1016\/j.aninu.2018.01.005\">https:\/\/doi.org\/10.1016\/j.aninu.2018.01.005<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Katalinic V., Milos M., Kulisic T., Jukic M. &#8220;Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols&#8221;. <em>Food Chemistry<\/em> (2006) 94(4):550-557. \u00a0<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1016\/j.foodchem.2004.12.004\">https:\/\/doi.org\/10.1016\/j.foodchem.2004.12.004<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">LeBel G., Vaillancourt K., Bercier P., Grenier D. &#8220;Antibacterial activity against porcine respiratory bacterial pathogens and in vitro biocompatibility of essential oils&#8221;. <em>Archives of Microbiology<\/em> (2019) 201:833-840; <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1007\/s00203-019-01655-7\">https:\/\/doi.org\/10.1007\/s00203-019-01655-7<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Lee KG, Shibamoto T. &#8220;Antioxidant activities of volatile components isolated from Eucalyptus species&#8221;. <em>Journal of the Science of Food and Agriculture<\/em> (2001). 81:1573-1597. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1002\/jsfa.980\">https:\/\/doi.org\/10.1002\/jsfa.980<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Liu SD, Song MH, Yun W, Lee JH, Lee CH, Kwak WG Han NS, Kim HB, Cho JH. &#8220;Effects of oral administration of different dosages of carvacrol essential oils on intestinal barrier function in broilers&#8221; <em>Journal of Animal Physiology and Animal Production <\/em>(2018) <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1111\/jpn.12944\">https:\/\/doi.org\/10.1111\/jpn.12944<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Murase K, Watanabe T, Arai S, Kim H, Tohya M, Ishida-Kuroki K, Vo T, Nguyen T, Nakagawa I, Osawa R, Nguyen N, Sekizaki T. &#8220;Characterization of pig saliva as the major natural habitat of <em>Streptococcus suis<\/em> by analyzing oral, fecal, vaginal, and environmental microbiota&#8221;. <em>PLoS ONE<\/em> (2019). 14(4). <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0215983%20\">https:\/\/doi.org\/10.1371\/journal.pone.0215983<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Nethmap MARAN report 2018. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.wur.nl\/upload_mm\/7\/b\/0\/5e568649-c674-420e-a2ca-acc8ca56f016_Maran%202018.pdf\">https:\/\/www.wur.nl\/upload_mm\/7\/b\/0\/5e568649-c674-420e-a2ca-acc8ca56f016_Maran%202018.pdf<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Penalver P, Huerta B, Borge C, Astorga R, Romero R, Perea A. &#8220;Antimicrobial activity of 5 essential oils against origin strains of the Enterobacteriaceae family&#8221;.<em> Acta Pathologica Microbiologica, et Immunologica Scandinavica<\/em> (2005) 113:1-6. <span style=\"text-decoration: underline;\"><a href=\"http:\/\/www.aromaticscience.com\/antimicrobial-activity-of-five-essential-oils-against-origin-strains-of-the-enterobacteriaceae-family\/\">AromaticScience, LLC Antimicrobial activity of five essential oils against origin strains of the Enterobacteriaceae family.<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Serafino A, Vallebona PS, Adnreola F, Zonfrillo M, Mercuri L, Federici M, Rasi G, Garaci E, Pierimarchi P. &#8220;Stimulatory effect of Eucalyptus essential oil on innate cell-mediated immune response&#8221; <em>BioMed Central <\/em>(2008). 9:17 <span style=\"text-decoration: underline;\"><a href=\"https:\/\/bmcimmunol.biomedcentral.com\/articles\/10.1186\/1471-2172-9-17\">https\/\/:doi:10.1186\/1471-2172-9-17<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Swildens B, Stockhofe-Zurwieden N, van der Meulen J, Wisselink HJ, Nielen M. \u201cIntestinal translocation of Streptococcus suis type 2 EF+ in pigs\u201d. <em>Veterinary Microbiology<\/em> (2004) 103:29-33. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi:%2010.1016\/j.vetmic.2004.06.010\">https:\/\/doi: 10.1016\/j.vetmic.2004.06.010<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Vande Maele L, Heyndrickx M, Maes D, De Pauw N, Mahu M, Verlinden M, Haesbrouck F, Martel A, Pasmans F, Boyen F. &#8220;In vitro susceptibility of <em>Brachyspira hyodysenteriae<\/em> to organic acids and essential oil components&#8221;. <em>Journal of Veterinary Medical Science<\/em> (2016). 78(2):325-328. \u00a0<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10\/1292\/jvms.15-0341\">https:\/\/doi.org\/10\/1292\/jvms.15-0341<\/a><\/span><\/span><\/p>\n<p><span style=\"font-size: 10pt;\">Zeng Z, Zhang S, Wang H, Piao X. &#8220;Essential oil and aromatic plants as feed additives in non-ruminant nutrition: a review&#8221;. <em>Journal of Animal Science and Biotechnology<\/em> (2015) 6:7. <span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org?10\/1186\/s40104-015-004-5\">https:\/\/doi.org?10\/1186\/s40104-015-004-5<\/a><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>by\u00a0 Merideth Parke, Regional Technical Manager, EW Nutrition To contain and reverse antimicrobial resistance, consumers and government regulators expect changes in pork production with the clear goal to reduce antibiotic use.\u00a0For healthy, profitable pig production with simultaneous antibiotic reduction, a holistic strategy is required: refocusing human attitudes and habits, optimal pig health and welfare, and&#8230;<\/p>\n","protected":false},"author":8,"featured_media":71382,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8039,8031,8043,8778],"tags":[3351,4004],"class_list":["post-146265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antibiotic-reduction-en-uk-2","category-pig-en-uk","category-pig-gut-health-en-uk","category-pig-nutrition-en-uk","tag-activo-en-uk","tag-phytomolecules-en-uk"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How phytomolecules support antibiotic reduction in pig production - EW Nutrition<\/title>\n<meta name=\"description\" content=\"What is the role of phytomolecules in antibiotic reduction? Find out how they provide health support for pigs through ABR strategies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How phytomolecules support antibiotic reduction in pig production\" \/>\n<meta property=\"og:description\" content=\"What is the role of phytomolecules in antibiotic reduction? Find out how they provide health support for pigs through ABR strategies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/\" \/>\n<meta property=\"og:site_name\" content=\"EW Nutrition\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-23T05:33:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-09-21T06:11:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/featured-images\/swine_schmidtkord.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"EW Nutrition\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@EWNutritionGmbH\" \/>\n<meta name=\"twitter:site\" content=\"@EWNutritionGmbH\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"EW Nutrition\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"How phytomolecules support antibiotic reduction in pig production - EW Nutrition","description":"What is the role of phytomolecules in antibiotic reduction? Find out how they provide health support for pigs through ABR strategies.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/","og_locale":"en_US","og_type":"article","og_title":"How phytomolecules support antibiotic reduction in pig production","og_description":"What is the role of phytomolecules in antibiotic reduction? Find out how they provide health support for pigs through ABR strategies.","og_url":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/","og_site_name":"EW Nutrition","article_published_time":"2021-04-23T05:33:04+00:00","article_modified_time":"2022-09-21T06:11:29+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/featured-images\/swine_schmidtkord.jpg","type":"image\/jpeg"}],"author":"EW Nutrition","twitter_card":"summary_large_image","twitter_creator":"@EWNutritionGmbH","twitter_site":"@EWNutritionGmbH","twitter_misc":{"Written by":"EW Nutrition","Est. reading time":"9 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/#article","isPartOf":{"@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/"},"author":{"name":"EW Nutrition","@id":"https:\/\/ew-nutrition.com\/#\/schema\/person\/b37875ffe5024c60729cdec33124a590"},"headline":"How phytomolecules support antibiotic reduction in pig production","datePublished":"2021-04-23T05:33:04+00:00","dateModified":"2022-09-21T06:11:29+00:00","mainEntityOfPage":{"@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/"},"wordCount":1825,"publisher":{"@id":"https:\/\/ew-nutrition.com\/#organization"},"image":{"@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/#primaryimage"},"thumbnailUrl":"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/featured-images\/swine_schmidtkord.jpg","keywords":["Activo","phytomolecules"],"articleSection":["Antibiotic reduction","Pig","Pig gut health","Pig nutrition"],"inLanguage":"en-gb"},{"@type":"WebPage","@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/","url":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/","name":"How phytomolecules support antibiotic reduction in pig production - EW Nutrition","isPartOf":{"@id":"https:\/\/ew-nutrition.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/#primaryimage"},"image":{"@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/#primaryimage"},"thumbnailUrl":"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/featured-images\/swine_schmidtkord.jpg","datePublished":"2021-04-23T05:33:04+00:00","dateModified":"2022-09-21T06:11:29+00:00","description":"What is the role of phytomolecules in antibiotic reduction? Find out how they provide health support for pigs through ABR strategies.","breadcrumb":{"@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/#breadcrumb"},"inLanguage":"en-gb","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/"]}]},{"@type":"ImageObject","inLanguage":"en-gb","@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/#primaryimage","url":"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/featured-images\/swine_schmidtkord.jpg","contentUrl":"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/featured-images\/swine_schmidtkord.jpg","width":1920,"height":1080,"caption":"swine schmidtkord"},{"@type":"BreadcrumbList","@id":"https:\/\/ew-nutrition.com\/en-uk\/phytomolecules-for-pig-antibiotic-reduction\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/ew-nutrition.com\/en-uk\/"},{"@type":"ListItem","position":2,"name":"How phytomolecules support antibiotic reduction in pig production"}]},{"@type":"WebSite","@id":"https:\/\/ew-nutrition.com\/#website","url":"https:\/\/ew-nutrition.com\/","name":"EW Nutrition","description":"Functional Innovations backed by Science","publisher":{"@id":"https:\/\/ew-nutrition.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ew-nutrition.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-gb"},{"@type":"Organization","@id":"https:\/\/ew-nutrition.com\/#organization","name":"EW Nutrition GmbH","url":"https:\/\/ew-nutrition.com\/","logo":{"@type":"ImageObject","inLanguage":"en-gb","@id":"https:\/\/ew-nutrition.com\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"EW Nutrition GmbH"},"image":{"@id":"https:\/\/ew-nutrition.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/EWNutritionGmbH","https:\/\/www.instagram.com\/ewnutrition\/","https:\/\/www.linkedin.com\/company\/ew-nutrition","https:\/\/www.youtube.com\/channel\/UCIvcb19uSOJXrUecTY8n_dA"]},{"@type":"Person","@id":"https:\/\/ew-nutrition.com\/#\/schema\/person\/b37875ffe5024c60729cdec33124a590","name":"EW Nutrition","description":"Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua.","url":"https:\/\/ew-nutrition.com\/en-uk\/author\/mbuller\/"}]}},"_links":{"self":[{"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/posts\/146265","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/comments?post=146265"}],"version-history":[{"count":0,"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/posts\/146265\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/media\/71382"}],"wp:attachment":[{"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/media?parent=146265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/categories?post=146265"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ew-nutrition.com\/en-uk\/wp-json\/wp\/v2\/tags?post=146265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}