{"id":101456,"date":"2022-07-06T08:25:32","date_gmt":"2022-07-06T06:25:32","guid":{"rendered":"https:\/\/ew-nutrition.com\/?p=101456"},"modified":"2023-06-09T10:31:59","modified_gmt":"2023-06-09T08:31:59","slug":"pushing-microbiome-in-right-direction-phytomolecules","status":"publish","type":"post","link":"https:\/\/ew-nutrition.com\/en-uk\/pushing-microbiome-in-right-direction-phytomolecules\/","title":{"rendered":"Efficient microbiome modulation with phytomolecules"},"content":{"rendered":"<p><span style=\"font-size: 12pt;\"><em>By <strong>Dr. Inge Heinzl<\/strong>, Editor, EW Nutrition<\/em><\/span><\/p>\n<p><strong>From day 1, young animals are confronted with the pathogens of their environment. Feed and feed ingredients also significantly increase exposure to microbes. This article will look closely at three critical bacteria in poultry production. The trials of phytomolecules-based products shared in this article prove the unique benefit of lowering harmful pathogens while simultaneously sparing health-promoting microbes. The targeted selection of the blend&#8217;s phytomolecules contributes to this distinctive mode of action.<\/strong><\/p>\n<h2><i><span lang=\"EN-US\">E. coli<\/span><\/i><span lang=\"EN-US\"> can be valuable&#8230; and dangerous<\/span><\/h2>\n<p>E.coli<span style=\"font-family: 'Open Sans', sans-serif; font-size: 17px;\"> are commensal bacteria that usually belong to the natural gut flora. However, there are several <\/span>E. coli<span style=\"font-family: 'Open Sans', sans-serif; font-size: 17px;\"> strains that, due to certain virulence factors, can cause disease. These bacteria are called avian pathogenic <\/span>E. coli<span style=\"font-family: 'Open Sans', sans-serif; font-size: 17px;\"> or APEC. The disease &#8216;Colibacillosis&#8217; can occur in different forms:<\/span><\/p>\n<ul>\n<li>Omphalitis \u2013 a noncontagious infection of the navel and\/or yolk sac in young poultry<\/li>\n<li>peritonitis \u2013 inflammatory response on &#8220;internal laying&#8221; (yolk material in the peritoneum)<\/li>\n<li>salpingitis \u2013 inflammation of the oviduct<\/li>\n<li>cellulitis \u2013 discoloration and thickening of the skin, inflammation of the subcutaneous tissues<\/li>\n<li>synovitis \u2013 lameness with swollen joints<\/li>\n<li>coligranuloma (Hj\u00e4rre disease) \u2013 lesions similar to tuberculosis, not of economic importance<\/li>\n<li>meningitis, and<\/li>\n<li>septicemia or blood poisoning.<\/li>\n<\/ul>\n<p>Since some of the <em>E. coli<\/em> strains can sometimes be transmitted vertically to offspring, it is crucial to keep the pathogenic pressure in the parent generation as low as possible (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.poultryworld.net\/health-nutrition\/escherichia-coli-infections-in-broiler-production\/#:~:text=The%20recommendations%20follow%20a%20ProHealth,coli%20was%20the%20dominant%20condition.\" target=\"_blank\" rel=\"noopener\">Mc Dougal, 2018<\/a><\/span>).<\/p>\n<p>Due to the, mostly in young chicks, common use of antibiotics, <em>E. coli<\/em> strains resistant to \u00df-lactam antibiotics (ESBL-producing <em>E. coli<\/em>) or fluoroquinolones (e.g., Enrofloxacin) have developed.<\/p>\n<h2>Clostridium perfringens: the cause of necrotic enteritis<\/h2>\n<p><em>Clostridium perfringens<\/em> belong to the normal caecal flora. However, its overgrowth in the intestine is linked to <a href=\"https:\/\/ew-nutrition.com\/en-uk\/necrotic-enteritis-the-complete-overview\/\" target=\"_blank\" rel=\"noopener\">necrotic enteritis<\/a>, causing estimated losses of up to USD 6 billion yearly in global poultry production, which corresponds to USD 0.0625 per bird (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/doi.org\/10.1016\/j.vetmic.2015.09.019\" target=\"_blank\" rel=\"noopener\">Wade and Keyburn, 2015<\/a><\/span>). Necrotic enteritis can occur in a clinical and a subclinical form.<\/p>\n<p>In the case of clinical necrotic enteritis, the birds suffer from diarrhea resulting in wet litter and increased flock mortality of up to 1 % per day (Ducatelle and Van Immerseel, 2010). Mortality rates sometimes sum up to 50 % (Van der Sluis, 2013). If birds die without clinical signs, it may be peracute necrotic enteritis.<\/p>\n<p>The subclinical version, however, is more critical. Due to the lack of symptoms, it often remains undetected and, therefore, not treated. Mainly through the impaired utilization of feed, representing 65-75 % of the total costs in broiler production, subclinical necrotic enteritis permanently impacts production efficiency (<span style=\"text-decoration: underline;\"><a href=\"https:\/\/ew-nutrition.com\/en-uk\/necrotic-enteritis-the-complete-overview\/\" target=\"_blank\" rel=\"noopener\">Heinzl et al., 2020<\/a><\/span>).<\/p>\n<h2><span lang=\"EN-US\">Salmonella enterica: a zoonosis relevant for birds and humans<\/span><\/h2>\n<p>Most concerning in (non-typhoid) salmonellosis is that it can be transferred to humans. The transmission occurs via direct contact with an infected animal, consuming contaminated animal products such as meat or eggs, contact with infected vectors (insects or pets) or contaminated equipment, or cross-contamination in the kitchen. Frozen or raw chicken products, as well as the eggs, are frequent causes of animal-origin Salmonella infections in humans.<\/p>\n<p>Salmonella is the more critical the younger the birds. If the hatching eggs already carry salmonellae, the hatchability dwindles. During their first weeks of life, infected chicks show higher mortality and systemic infections.<\/p>\n<p>Adult animals usually do not die from salmonellosis; often, the infection remains unnoticed. During an acute salmonella outbreak, the animals might show weakness and diarrhea. They lose weight, resulting in decreased egg production in layers.<\/p>\n<h2><span lang=\"EN-US\">Trials with phytomolecules show promising results<\/span><\/h2>\n<p>To check if phytomolecules-based products can effectively influence gut flora, a product specially designed for gut health (<a href=\"https:\/\/ew-nutrition.com\/en-uk\/animal-nutrition\/products\/ventar-d\/\" target=\"_blank\" rel=\"noopener\">Ventar D<\/a>) was tested for its antimicrobial activity. Additionally, the extent to which the same blend impacted the beneficial bacteria, such as Lactobacilli, was evaluated.<\/p>\n<h4><span lang=\"EN-US\">Trial 1: phytomolecules act against <i>E. coli<\/i> and <i>Salmonella enterica<\/i><\/span><\/h4>\n<p>The in vitro study using the agar dilution method was conducted at a German laboratory.<\/p>\n<p>The bacteria (<em>Salmonella typhimurium<\/em> and ESBL-producing <em>E. coli<\/em>) stored at -80\u00b0C were reactivated by cultivating them on Agar Mueller Hinton overnight. After this incubation, some colonies were picked and suspended in 1 ml 0.9% NaCl solution. 100 \u00b5l of the suspension were pipetted and evenly spread (plate spread technique) on new Agar Mueller Hinton containing different concentrations of a phytomolecules-based product (Ventar D): 0 \u00b5g\/mL \u2013 control; 500 \u00b5g\/mL; 900 \u00b5g\/mL; 1.250 \u00b5g\/mL and 2.500 \u00b5g\/mL. After 16-20 h incubation at 37\u00b0C, growth was evaluated. The results can be seen in pictures 1 and 2:<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"wp-image-101309 size-full aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e.jpg\" alt=\"\" width=\"600\" height=\"402\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e.jpg 600w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-300x201.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-150x101.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-120x80.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-36x24.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-225x151.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-80x54.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-48x32.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-64x43.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-1_e-28x19.jpg 28w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><em><span style=\"font-size: 10pt;\">Figure 1: E. coli exposed to different concentrations of Ventar D (upper row from left to right: control 0 \u00b5g\/ml, 500 \u00b5g\/ml, 900 \u00b5g\/ml; lower row from left to right: 1250 \u00b5g\/ml and 2500 \u00b5g\/ml)<\/span><\/em><\/p>\n<p style=\"text-align: left;\"><em>E. coli<\/em> colonies exposed to 900 \u00b5g\/mL of Ventar D&#8217;s phytogenic formulation were smaller than the control colonies. At 1250 \u00b5g\/mL, fewer colonies were detected, and at 2500 \u00b5g\/mL, growth couldn&#8217;t be seen anymore.<\/p>\n<p style=\"text-align: left;\">The salmonella colonies showed a similar picture; however, the reduction could be seen from a concentration of 1.250 \u00b5g\/ml of Ventar D onwards (picture 2).<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"wp-image-101149 size-full aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to.jpg\" alt=\"\" width=\"600\" height=\"403\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to.jpg 600w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-300x202.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-150x101.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-120x81.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-36x24.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-225x151.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-80x54.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-48x32.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-64x43.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-2_salmonella-enterica-exposed-to-28x19.jpg 28w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><em><span style=\"font-size: 10pt;\">Figure 2: Salmonella enterica exposed to different concentrations of Ventar D (upper row from left to right: control 0 \u00b5g\/ml, 500 \u00b5g\/ml, 900 \u00b5g\/ml; lower row from left to right: 1250 \u00b5g\/ml and 2500 \u00b5g\/ml)<\/span><\/em><\/p>\n<h2>Trial 2: Phytomolecules inhibit Clostridium perfringens and spare Lactobacilli<\/h2>\n<p>In this trial, the bacteria (<em>Clostridium perfringens,<\/em> <em>Lactobacillus agilis S73<\/em>, and <em>Lactobacillus plantarum<\/em>) were cultured under favorable conditions (RCM, 37\u00b0C, anaerobe for Clostr. perfr., and MRS, 37\u00b0C, 5 % CO<sub>2<\/sub> for Lactobacilli) and exposed to different concentrations of Ventar D (0 \u00b5g\/ml \u2013 control, 500 \u00b5g\/ml, 750 \u00b5g\/ml, and 1000 \u00b5g\/ml).<\/p>\n<p>The results are shown in figures 3a-d.<\/p>\n<div class=\"row postid-101141-row\">\n<div class=\"vc_col-sm-3\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-101181 aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a.jpg 260w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-130x150.jpg 130w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-104x120.jpg 104w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-31x36.jpg 31w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-195x225.jpg 195w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-69x80.jpg 69w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-42x48.jpg 42w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-55x64.jpg 55w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3a-24x28.jpg 24w\" sizes=\"(max-width: 260px) 100vw, 260px\" \/><em><span style=\"font-size: 10pt;\">Figure 3a: control, 0 \u00b5g\/ml<\/span><\/em><\/p>\n<\/div>\n<div class=\"vc_col-sm-3\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-101213 aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b.jpg 260w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-130x150.jpg 130w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-104x120.jpg 104w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-31x36.jpg 31w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-195x225.jpg 195w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-69x80.jpg 69w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-42x48.jpg 42w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-55x64.jpg 55w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3b-24x28.jpg 24w\" sizes=\"(max-width: 260px) 100vw, 260px\" \/><em><span style=\"font-size: 10pt;\">Figure 3b: 500 \u00b5g\/ml<\/span><\/em><\/p>\n<\/div>\n<div class=\"vc_col-sm-3\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-101245 aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c.jpg 260w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-130x150.jpg 130w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-104x120.jpg 104w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-31x36.jpg 31w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-195x225.jpg 195w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-69x80.jpg 69w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-42x48.jpg 42w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-55x64.jpg 55w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3c-24x28.jpg 24w\" sizes=\"(max-width: 260px) 100vw, 260px\" \/><em><span style=\"font-size: 10pt;\">Figure 3c: 750 \u00b5g\/ml<\/span><\/em><\/p>\n<\/div>\n<div class=\"vc_col-sm-3\">\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"size-full wp-image-101277 aligncenter\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d.jpg\" alt=\"\" width=\"260\" height=\"300\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d.jpg 260w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-130x150.jpg 130w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-104x120.jpg 104w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-31x36.jpg 31w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-195x225.jpg 195w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-69x80.jpg 69w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-42x48.jpg 42w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-55x64.jpg 55w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-3d-24x28.jpg 24w\" sizes=\"(max-width: 260px) 100vw, 260px\" \/><em><span style=\"font-size: 10pt;\">Figure 3d: 1000 \u00b5g\/m<\/span><\/em><\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>In the case of Clostridium perfringens, a significant reduction of colonies could already be observed at a concentration of 500 \u00b5g\/ml of Ventar D. At 750 \u00b5g\/ml, only a few colonies remained. At a Ventar D concentration of 1000 \u00b5g\/ml, Clostridium perfringens could no longer grow.<\/p>\n<p>In contrast to Clostridium, the Lactobacilli showed a different picture: only at the higher concentration (1250 \u00b5g\/ml of Ventar D), Lactobacillus plantarum and Lactobacillus agilis S73 showed a slight growth reduction (figures 4 and 5).<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter wp-image-101341 size-full\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4.jpg\" alt=\"\" width=\"600\" height=\"305\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4.jpg 600w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-300x153.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-150x76.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-120x61.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-36x18.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-225x114.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-80x41.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-48x24.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-64x33.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-4-28x14.jpg 28w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><em><span style=\"font-size: 10pt;\">Figure 4: Lactobacillus plantarum exposed to 0 (left) and 1250 \u00b5g\/ml (right) of Ventar D<\/span><\/em><\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter wp-image-101373 size-full\" src=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5.jpg\" alt=\"\" width=\"600\" height=\"292\" srcset=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5.jpg 600w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-300x146.jpg 300w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-150x73.jpg 150w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-120x58.jpg 120w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-36x18.jpg 36w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-225x110.jpg 225w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-80x39.jpg 80w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-48x23.jpg 48w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-64x31.jpg 64w, https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/pushing-the-microbiome-in-the-right-direction....with-phytomolecules\/figure-5-28x14.jpg 28w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><em><span style=\"font-size: 10pt;\">Figure 5: Lactobacillus agilis S73 exposed to 0 (left) and 1250 \u00b5g\/ml (right) of Ventar D<\/span><\/em><\/p>\n<h2>Improve gut health by positively influencing the intestinal flora<\/h2>\n<p>The experiments show that even at lower concentrations, phytomolecules impair the growth of harmful bacteria while sparing the beneficial ones. Phytomolecule-based products can be regarded as a valuable tool for controlling relevant pathogens in poultry and influencing the microflora composition in a positive way.<\/p>\n<p>The resulting better gut health is the best precondition to reducing antibiotics in animal production.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>By Dr. Inge Heinzl, Editor, EW Nutrition From day 1, young animals are confronted with the pathogens of their environment. Feed and feed ingredients also significantly increase exposure to microbes. This article will look closely at three critical bacteria in poultry production. The trials of phytomolecules-based products shared in this article prove the unique benefit&#8230;<\/p>\n","protected":false},"author":5,"featured_media":101428,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8796,8030],"tags":[4004],"class_list":["post-101456","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phytomolecules-en-uk-2","category-poultry-en-uk","tag-phytomolecules-en-uk"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.5 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Efficient microbiome modulation with phytomolecules - EW Nutrition<\/title>\n<meta name=\"description\" content=\"Trials with a blend of selected phytomolecules showed an inhibiting effect on the poultry-critical bacteria E. coli, salmonella, and clostridium perfringens with simultaneously sparing the beneficial lactobacilli.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ew-nutrition.com\/en-uk\/pushing-microbiome-in-right-direction-phytomolecules\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Efficient microbiome modulation with phytomolecules\" \/>\n<meta property=\"og:description\" content=\"Trials with a blend of selected phytomolecules showed an inhibiting effect on the poultry-critical bacteria E. coli, salmonella, and clostridium perfringens with simultaneously sparing the beneficial lactobacilli.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ew-nutrition.com\/en-uk\/pushing-microbiome-in-right-direction-phytomolecules\/\" \/>\n<meta property=\"og:site_name\" content=\"EW Nutrition\" \/>\n<meta property=\"article:published_time\" content=\"2022-07-06T06:25:32+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-06-09T08:31:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ew-nutrition.com\/wp-content\/uploads\/articles\/featured-images\/gut-bacteria.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"518\" \/>\n\t<meta property=\"og:image:height\" content=\"574\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"EW Nutrition\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@EWNutritionGmbH\" \/>\n<meta name=\"twitter:site\" content=\"@EWNutritionGmbH\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"EW Nutrition\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Efficient microbiome modulation with phytomolecules - 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